Juvederm Ultra 4 (2 x 1ml)

Juvederm Series · Deep folds, cheekbone, chin contouring Juvederm Ultra 4 — Hylacross HA Filler for Deep Wrinkles & Facial Volumising Juvederm Ultra 4 is Allergan’s deepest Hylacross-series filler — 24 mg/mL cross-linked HA 0.3% lidocaine engineered for deep dermal placement. Volumising capacity 4/5. Targets deep nasolabial folds, cheekbone augmentation, and chin contouring. Manufactured in France with CE 0459 marking; 2 x 1 mL syringes per box. Professional use only — for licensed aesthetic practitioners. Manufacturer: Allergan / AbbVie, France · Established 1948 Hylacross Volumising 4/5 2 × 1mL Per Box May 2026 Last Reviewed · Verified Allergan / AbbVie Technology How Juvederm Ultra 4 with Lidocaine (2 x 1ml) Is Engineered 1 Patented Hylacross Cross-Linking Technology Allergan / AbbVie’s proprietary cross-linking process produces a stabilised HA gel matrix engineered for sustained tissue retention. The technology balances viscoelasticity (firmness for projection) with extrusion smoothness (easier injection through the 27G 1/2″ needle). The result: predictable handling, consistent gel distribution, and Up to 12 months durability in deep dermis placement. 2 Quality & Purity Non-animal hyaluronic acid produced by bacterial fermentation. Endotoxin levels controlled below international safety thresholds. Stringent manufacturing under GMP-certified conditions minimises BDDE residue, heavy metals, and protein contaminants — reducing the risk of post-injection inflammation, granuloma formation, or hypersensitivity reactions in suitable patient profiles. Composition Juvederm Ultra 4 with Lidocaine (2 x 1ml) Active Ingredients Cross-Linked Hyaluronic Acid 24 mg/mL Non-animal hyaluronic acid produced by bacterial fermentation, cross-linked using Allergan / AbbVie’s Patented Hylacross Cross-Linking Technology technology. The cross-linking process creates a stable, durable gel matrix that resists rapid enzymatic breakdown in tissue. Phosphate-buffered saline carries the gel at near-physiological pH. Lidocaine HCl 0.3% (3 mg/mL) Premixed local anaesthetic at the industry-standard 0.3% concentration. Reduces injection-site discomfort and eliminates the need for on-site mixing with separate lidocaine vials. The lidocaine itself wears off within hours of injection and does not affect long-term gel duration. Clinical Indications Where Juvederm Ultra 4 with Lidocaine (2 x 1ml) Is Used Deep Nasolabial Folds Primary indication. Pronounced nose-to-mouth folds via deep dermal injection. Cheekbone Augmentation Midface volumising via deep dermal-to-subcutaneous placement. Chin Contouring Chin projection and profile enhancement. Off-label deep placement standard. Lip Hemming & Enlargement Significant lip body volumising via deep dermal placement. Side-By-Side Juvederm Ultra 4 with Lidocaine (2 x 1ml) vs Juvederm vs Restylane Feature Juvederm Juvederm (Allergan) Restylane (Galderma) HA Concentration 24 mg/mL 15–24 mg/mL 20 mg/mL Cross-Linking Tech Hylacross Vycross / Hylacross NASHA® / OBT Lidocaine 0.3% (premixed) 0.3% (XC lines) 0.3% (Lidocaine variants) Duration Up to 12 months 6–24 months (varies) 6–18 months (varies) Origin France (Allergan / AbbVie) USA (Allergan / AbbVie) Sweden (Galderma) Established Since 1948 2006 1996 ↔ Swipe horizontally on mobile to view all columns Comparison based on manufacturer published data. See our top dermal filler comparison guide for broader market context. Specifications Juvederm Ultra 4 with Lidocaine (2 x 1ml) Product Specifications Manufacturer Brand: Juvederm Company: Allergan / AbbVie Country: France Established: 1948 Formula HA Source: Non-animal bacterial fermentation HA Concentration: 24 mg/mL Lidocaine: 0.3% (3 mg/mL) premixed Cross-linking: Patented Hylacross Cross-Linking Technology Performance Duration: Up to 12 months Injection Depth: Deep dermis Recommended Needle: 27G 1/2″ Last Reviewed: May 2026 Approval & Storage Approvals: CE 0459 · Class III Medical Device · Manufactured in France Packaging: 2 x 1 mL pre-filled syringes 4 x 27G 1/2″ needles Storage: 2–25 °C, do not freeze Shelf life: 24 months unopened Verify regulatory status at the official Korean MFDS database — nedrug.mfds.go.kr. For market pricing context, see our dermal filler pricing guide. FAQs Juvederm Ultra 4 with Lidocaine (2 x 1ml) — Frequently Asked Questions What is Juvederm Ultra 4 with Lidocaine (2 x 1ml)? Juvederm Ultra 4 is Allergan’s deepest Hylacross-series filler — 24 mg/mL cross-linked HA 0.3% lidocaine engineered for deep dermal placement. Volumising capacity 4/5. Targets deep nasolabial folds, cheekbone augmentation, and chin contouring. Manufactured in France with CE 0459 marking; 2 x 1 mL syringes per box. Where is Juvederm Ultra 4 with Lidocaine (2 x 1ml) manufactured? Juvederm Ultra 4 with Lidocaine (2 x 1ml) is manufactured by Allergan / AbbVie, a France-based medical device and pharmaceutical company established in 1948. The product is part of the Juvederm dermal filler range, which is distributed across multiple international markets. Regulatory status: CE 0459 · Class III Medical Device · Manufactured in France. What is the HA concentration in Juvederm Ultra 4 with Lidocaine (2 x 1ml)? Juvederm Ultra 4 with Lidocaine (2 x 1ml) contains 24 mg/mL of cross-linked hyaluronic acid plus 0.3% (3 mg/mL) premixed lidocaine for injection comfort. The hyaluronic acid is non-animal, produced by bacterial fermentation and cross-linked using Allergan / AbbVie’s Patented Hylacross Cross-Linking Technology technology. Phosphate-buffered saline at near-physiological pH carries the gel. How long do Juvederm Ultra 4 with Lidocaine (2 x 1ml) results last? Per Allergan / AbbVie’s clinical data, Juvederm Ultra 4 with Lidocaine (2 x 1ml) delivers Up to 12 months of correction depending on placement and patient factors. Duration depends on injection depth, dose, anatomical site, patient metabolism, and facial movement intensity. Deep dermis placement typically delivers the longer end of the duration range. What is the recommended injection depth for Juvederm Ultra 4 with Lidocaine (2 x 1ml)? Juvederm Ultra 4 with Lidocaine (2 x 1ml) is engineered for deep dermis placement. The standard recommended needle is 27G 1/2″, supplied in the syringe blister pack. Some practitioners prefer a blunt-tip cannula of equivalent gauge for safer placement in highly vascular zones, particularly for deeper subcutaneous work. Is Juvederm Ultra 4 with Lidocaine (2 x 1ml) FDA approved or CE marked? Juvederm Ultra 4 with Lidocaine (2 x 1ml) regulatory status: CE 0459 · Class III Medical Device · Manufactured in France. The product’s KFDA registration in South Korea is the primary regulatory baseline. CE marking and other international approvals enable distribution in the EU and other regulated markets. US FDA status varies — buyers in regulated jurisdictions should verify approval scope before importation and clinical use. How should Juvederm Ultra 4 with Lidocaine (2 x 1ml) be stored at the clinic? Store Juvederm Ultra 4 with Lidocaine (2 x 1ml) between 2 °C and 25 °C in original packaging, away from direct sunlight. Do not freeze — freezing damages the HA gel structure. Shelf life is typically 24 months from the manufacturing date printed on the box when unopened. Once a syringe is opened, contents must be used immediately. Partial syringes cannot be retained for later use due to sterility risk. Does Juvederm Ultra 4 with Lidocaine (2 x 1ml) contain animal-derived ingredients? No. Juvederm Ultra 4 with Lidocaine (2 x 1ml) uses non-animal hyaluronic acid produced by bacterial fermentation — the standard manufacturing approach for modern HA dermal fillers. The product contains no animal proteins or by-products, making it suitable for patients who avoid animal-derived medical products. The product is contraindicated in patients with severe allergies to gram-positive bacterial proteins (used in HA fermentation). Can Juvederm Ultra 4 with Lidocaine (2 x 1ml) be combined with other dermal fillers in the same session? Yes — layered protocols combining different fillers are standard aesthetic practice. Juvederm Ultra 4 with Lidocaine (2 x 1ml) can be combined with other Korean or international HA fillers, neuromodulators (botulinum toxin), or biostimulators (PLLA, calcium hydroxylapatite) within a single session. Always wait the recommended interval between different injectable products and confirm biocompatibility per each manufacturer’s IFU. Is Juvederm Ultra 4 the same as Voluma? No — Ultra 4 and Voluma are different products with different cross-linking technologies. Ultra 4 uses older Hylacross technology (24 mg/mL HA, 2 x 1 mL pack, volumising 4/5). Voluma uses newer Vycross technology (20 mg/mL HA, designed for deeper subcutaneous cheek/chin augmentation with up to 18-month durability). Voluma is FDA approved for cheek augmentation; Ultra 4 is CE-marked but not US FDA approved as a separate product. Both work in similar treatment zones but differ in clinical performance profile. 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Browse category → Important Safety Information Read Before Clinical Use Juvederm Ultra 4 with Lidocaine (2 x 1ml) is a prescription medical device for use only by licensed aesthetic practitioners. Common reactions include injection-site bruising, swelling, redness, and tenderness — generally resolving within days. Like all hyaluronic acid dermal fillers, treatment carries rare but serious vascular complication risks. Contraindicated in patients with known hypersensitivity to hyaluronic acid or lidocaine, active skin infection at the treatment site, pregnancy, or breastfeeding. Full contraindications, vascular complication protocols, aftercare, and emergency guidance are detailed on the dermal filler safety page. Read Full Dermal Filler Safety Information → Juvederm is a registered trademark of Allergan / AbbVie. Fillersfairy.com is a channel distributor and does not provide medical advice. This page is for informational purposes only and does not replace the manufacturer’s official Instructions for Use, which remains the authoritative source for clinical administration. Regulatory status varies by jurisdiction — buyers are responsible for verifying legal status before ordering. Last reviewed May 2026 against Allergan / AbbVie manufacturer documentation.