Juvederm Ultra Smile (2 x 0.55ml)

Juvederm Series · Lip augmentation, perioral lines, lip contour Juvederm Ultra Smile — Lip-Specific Hylacross HA Filler (2 x 0.55ml) Juvederm Ultra Smile is Allergan’s lip-specific formulation — 24 mg/mL Hylacross-cross-linked HA 0.3% lidocaine engineered specifically for lip body augmentation and perioral wrinkle correction. Volumising capacity 3/5. The soft consistency suits lip body placement and corner-of-mouth correction. 2 x 0.55 mL per box. Professional use only — for licensed aesthetic practitioners. Manufacturer: Allergan / AbbVie, France · Established 1948 Hylacross Lip-Specific 2 × 0.55mL Per Box May 2026 Last Reviewed · Verified Allergan / AbbVie Technology How Juvederm Ultra Smile with Lidocaine (2 x 0.55ml) Is Engineered 1 Patented Hylacross Cross-Linking Technology Allergan / AbbVie’s proprietary cross-linking process produces a stabilised HA gel matrix engineered for sustained tissue retention. The technology balances viscoelasticity (firmness for projection) with extrusion smoothness (easier injection through the 30G 1/2″ needle). The result: predictable handling, consistent gel distribution, and Up to 12 months durability in mid dermis (lip-specific) placement. 2 Quality & Purity Non-animal hyaluronic acid produced by bacterial fermentation. Endotoxin levels controlled below international safety thresholds. Stringent manufacturing under GMP-certified conditions minimises BDDE residue, heavy metals, and protein contaminants — reducing the risk of post-injection inflammation, granuloma formation, or hypersensitivity reactions in suitable patient profiles. Composition Juvederm Ultra Smile with Lidocaine (2 x 0.55ml) Active Ingredients Cross-Linked Hyaluronic Acid 24 mg/mL Non-animal hyaluronic acid produced by bacterial fermentation, cross-linked using Allergan / AbbVie’s Patented Hylacross Cross-Linking Technology technology. The cross-linking process creates a stable, durable gel matrix that resists rapid enzymatic breakdown in tissue. Phosphate-buffered saline carries the gel at near-physiological pH. Lidocaine HCl 0.3% (3 mg/mL) Premixed local anaesthetic at the industry-standard 0.3% concentration. Reduces injection-site discomfort and eliminates the need for on-site mixing with separate lidocaine vials. The lidocaine itself wears off within hours of injection and does not affect long-term gel duration. Clinical Indications Where Juvederm Ultra Smile with Lidocaine (2 x 0.55ml) Is Used Lip Body Augmentation Primary indication. Subtle-to-moderate lip volumising via lip mucosa injection using the nappage technique. Perioral Lines Smoker’s lines and lipstick lines around the mouth. The 30G 1/2″ needle suits this delicate zone. Lip Contour Definition Vermillion border refinement and lip shape correction. Corner-of-Mouth Asymmetry Subtle correction of asymmetric lip corners. Off-label use; conservative dosing essential. Side-By-Side Juvederm Ultra Smile with Lidocaine (2 x 0.55ml) vs Juvederm vs Restylane Feature Juvederm Juvederm (Allergan) Restylane (Galderma) HA Concentration 24 mg/mL 15–24 mg/mL 20 mg/mL Cross-Linking Tech Hylacross Vycross / Hylacross NASHA® / OBT Lidocaine 0.3% (premixed) 0.3% (XC lines) 0.3% (Lidocaine variants) Duration Up to 12 months 6–24 months (varies) 6–18 months (varies) Origin France (Allergan / AbbVie) USA (Allergan / AbbVie) Sweden (Galderma) Established Since 1948 2006 1996 ↔ Swipe horizontally on mobile to view all columns Comparison based on manufacturer published data. See our top dermal filler comparison guide for broader market context. Specifications Juvederm Ultra Smile with Lidocaine (2 x 0.55ml) Product Specifications Manufacturer Brand: Juvederm Company: Allergan / AbbVie Country: France Established: 1948 Formula HA Source: Non-animal bacterial fermentation HA Concentration: 24 mg/mL Lidocaine: 0.3% (3 mg/mL) premixed Cross-linking: Patented Hylacross Cross-Linking Technology Performance Duration: Up to 12 months Injection Depth: Mid dermis (lip-specific) Recommended Needle: 30G 1/2″ Last Reviewed: May 2026 Approval & Storage Approvals: CE 0459 · Class III Medical Device · Manufactured in France Packaging: 2 x 0.55 mL pre-filled syringes 2 x 30G 1/2″ needles Storage: 2–25 °C, do not freeze Shelf life: 24 months unopened Verify regulatory status at the official Korean MFDS database — nedrug.mfds.go.kr. For market pricing context, see our dermal filler pricing guide. FAQs Juvederm Ultra Smile with Lidocaine (2 x 0.55ml) — Frequently Asked Questions What is Juvederm Ultra Smile with Lidocaine (2 x 0.55ml)? Juvederm Ultra Smile is Allergan’s lip-specific formulation — 24 mg/mL Hylacross-cross-linked HA 0.3% lidocaine engineered specifically for lip body augmentation and perioral wrinkle correction. Volumising capacity 3/5. The soft consistency suits lip body placement and corner-of-mouth correction. 2 x 0.55 mL per box. Where is Juvederm Ultra Smile with Lidocaine (2 x 0.55ml) manufactured? Juvederm Ultra Smile with Lidocaine (2 x 0.55ml) is manufactured by Allergan / AbbVie, a France-based medical device and pharmaceutical company established in 1948. The product is part of the Juvederm dermal filler range, which is distributed across multiple international markets. Regulatory status: CE 0459 · Class III Medical Device · Manufactured in France. What is the HA concentration in Juvederm Ultra Smile with Lidocaine (2 x 0.55ml)? Juvederm Ultra Smile with Lidocaine (2 x 0.55ml) contains 24 mg/mL of cross-linked hyaluronic acid plus 0.3% (3 mg/mL) premixed lidocaine for injection comfort. The hyaluronic acid is non-animal, produced by bacterial fermentation and cross-linked using Allergan / AbbVie’s Patented Hylacross Cross-Linking Technology technology. Phosphate-buffered saline at near-physiological pH carries the gel. How long do Juvederm Ultra Smile with Lidocaine (2 x 0.55ml) results last? Per Allergan / AbbVie’s clinical data, Juvederm Ultra Smile with Lidocaine (2 x 0.55ml) delivers Up to 12 months of correction depending on placement and patient factors. Duration depends on injection depth, dose, anatomical site, patient metabolism, and facial movement intensity. Mid dermis (lip-specific) placement typically delivers the longer end of the duration range. What is the recommended injection depth for Juvederm Ultra Smile with Lidocaine (2 x 0.55ml)? Juvederm Ultra Smile with Lidocaine (2 x 0.55ml) is engineered for mid dermis (lip-specific) placement. The standard recommended needle is 30G 1/2″, supplied in the syringe blister pack. Some practitioners prefer a blunt-tip cannula of equivalent gauge for safer placement in highly vascular zones, particularly for deeper subcutaneous work. Is Juvederm Ultra Smile with Lidocaine (2 x 0.55ml) FDA approved or CE marked? Juvederm Ultra Smile with Lidocaine (2 x 0.55ml) regulatory status: CE 0459 · Class III Medical Device · Manufactured in France. The product’s KFDA registration in South Korea is the primary regulatory baseline. CE marking and other international approvals enable distribution in the EU and other regulated markets. US FDA status varies — buyers in regulated jurisdictions should verify approval scope before importation and clinical use. How should Juvederm Ultra Smile with Lidocaine (2 x 0.55ml) be stored at the clinic? Store Juvederm Ultra Smile with Lidocaine (2 x 0.55ml) between 2 °C and 25 °C in original packaging, away from direct sunlight. Do not freeze — freezing damages the HA gel structure. Shelf life is typically 24 months from the manufacturing date printed on the box when unopened. Once a syringe is opened, contents must be used immediately. Partial syringes cannot be retained for later use due to sterility risk. Does Juvederm Ultra Smile with Lidocaine (2 x 0.55ml) contain animal-derived ingredients? No. Juvederm Ultra Smile with Lidocaine (2 x 0.55ml) uses non-animal hyaluronic acid produced by bacterial fermentation — the standard manufacturing approach for modern HA dermal fillers. The product contains no animal proteins or by-products, making it suitable for patients who avoid animal-derived medical products. The product is contraindicated in patients with severe allergies to gram-positive bacterial proteins (used in HA fermentation). Can Juvederm Ultra Smile with Lidocaine (2 x 0.55ml) be combined with other dermal fillers in the same session? Yes — layered protocols combining different fillers are standard aesthetic practice. Juvederm Ultra Smile with Lidocaine (2 x 0.55ml) can be combined with other Korean or international HA fillers, neuromodulators (botulinum toxin), or biostimulators (PLLA, calcium hydroxylapatite) within a single session. Always wait the recommended interval between different injectable products and confirm biocompatibility per each manufacturer’s IFU. Why does Juvederm Ultra Smile have a smaller syringe size (0.55ml)? Juvederm Ultra Smile uses 2 x 0.55 mL syringes (1.1 mL total) rather than the 1 mL standard because lip work requires smaller incremental dosing than facial wrinkle work. Practitioners typically inject 0.2-0.5 mL per lip, making 0.55 mL the convenient unit per treatment. The smaller syringe reduces waste from partial use and supports the precision required in this high-visibility anatomical zone. Both syringes in a box may be used in a single comprehensive lip session or split across two consultations within the syringe’s sterile lifespan. Related Products Other HA Dermal Fillers on Fillersfairy Juvederm · France Juvederm Ultra 2 with Lidocaine (2 x 0.55ml) Juvederm Ultra 2 is Allergan’s lightest Hylacross-technology filler — 24 mg/mL cross-linked non-animal hyaluronic acid 0.3% l… View product → Juvederm · France Juvederm Ultra 3 with Lidocaine (2 x 1ml) Juvederm Ultra 3 is Allergan’s medium-density Hylacross filler — 24 mg/mL cross-linked HA 0.3% lidocaine produced by Streptoc… View product → Monalisa · South Korea Monalisa Soft with Lidocaine Monalisa Soft is GENOSS’s lightest variant — 24 mg/mL cross-linked HA 0.3% lidocaine with the smallest particle size (200µm) … View product → Category All Dermal Fillers Browse our full range of HA dermal fillers, lip fillers, body fillers, and skin boosters for facial volume, contouring, and rejuvenation. Browse category → Important Safety Information Read Before Clinical Use Juvederm Ultra Smile with Lidocaine (2 x 0.55ml) is a prescription medical device for use only by licensed aesthetic practitioners. Common reactions include injection-site bruising, swelling, redness, and tenderness — generally resolving within days. Like all hyaluronic acid dermal fillers, treatment carries rare but serious vascular complication risks. Contraindicated in patients with known hypersensitivity to hyaluronic acid or lidocaine, active skin infection at the treatment site, pregnancy, or breastfeeding. Full contraindications, vascular complication protocols, aftercare, and emergency guidance are detailed on the dermal filler safety page. Read Full Dermal Filler Safety Information → Juvederm is a registered trademark of Allergan / AbbVie. Fillersfairy.com is a channel distributor and does not provide medical advice. This page is for informational purposes only and does not replace the manufacturer’s official Instructions for Use, which remains the authoritative source for clinical administration. Regulatory status varies by jurisdiction — buyers are responsible for verifying legal status before ordering. Last reviewed May 2026 against Allergan / AbbVie manufacturer documentation.